Turmeric Curcumin and Colon Cancer 

The low incidence of  bowel cancer in India is often attributed to natural antioxidants such as curcumin, the yellow pigment in the spice turmeric, used in curry powder. However, it is important to remember that the benefits of a diet are seldom produced by a single ingredient in that diet. For example, diets rich in beta-carotene lower the risk of tobacco-related cancers, but beta-carotene pills do not. That doesn’t stop researchers from trying, though.

Back in 2001, in a last ditch attempt to save the lives of 15 patients with advanced colorectal cancer that didn’t respond to any of the standard chemotherapy agents or radiation, researchers started them on a turmeric extract. The extract appeared to help stall the disease in a third (5 out of 15) of the patients, suggesting that turmeric extract may clinically benefit at least some patients with advanced refractory colorectal cancer.

If we were talking about some new kind of chemotherapy, and it only helped one in three, we’d have to weigh the benefits against chemo side effects, such as losing our hair, the sloughing of our guts, intractable vomiting, maybe being bed-ridden. Therefore, a drug scenario, a one in three benefit may not sound particularly appealing. But when we’re talking about plant extract proven to be remarkably safe, it would be worth considering even if it just helped 1 in a 100. With no serious downsides, a one in three benefit for end-stage cancer is pretty exciting.

To see if colon cancer could be prevented, five years later, researchers at Cleveland Clinic and John Hopkins School of Medicine tested two phytochemicals, curcumin (from turmeric) and quercitin, (found in fruits and vegetables such as red onions and grapes) in people with familial adenomatous polyposis, an inherited form of colon cancer in which individuals develop hundreds of polyps that may become cancerous unless prophylactically removed. Researchers gave supplements of curcumin and quercetin to five such patients who already had their colons removed, but still had either polyps in their rectum or in a little intestinal pouch. Each patient had between 5 and 45 polyps each, but after six months on the supplement they ended up with on average fewer than half the polyps, and the ones that were left had shrunk in half. One patient got rid of all polyps by month three, but then they seemed to come back. The researchers asked the patient what’s what, and it turned out that the patient stopped taking the supplements. So researchers put the patient back on the phytonutrient supplements for another three months, and the polyps came back down with virtually no adverse events and no blood test abnormalities.

By studying people at high risk for colon cancer, the researchers were able to show noticeable effects within just months. But polyposis is a rare disease; they were only able to recruit five people for the study. Thankfully, smokers are a dime a dozen. After another five years, researchers put 44 smokers on turmeric curcumin supplements alone for a month and measured changes in their colorectal aberrant crypt foci, which may act like the precursors to polyps, which are the precursors to cancer. After just one month there was a significant drop in the number of these abnormal crypt foci in the high dose supplement group but no change in the low dose group. There were also no dose-limiting side effects (although the stools in the participants did turn yellow).

More on turmeric and Cancer in Carcinogenic Blocking Effects of Turmeric and Turmeric Curcumin Reprogramming Cancer Cell Death. 

Who hasn’t felt that heavy, achy feeling of overworked muscles? You know the kind—it’s the type that settles in a day or two after exercising beyond one’s current level of fitness. I tend to experience this sort of thing at the first sight of spring when I overzealously hit my gardens and orchard as though all of this yard work must be accomplished in a single day. Wouldn’t it be nice to stop it in its tracks? Or better yet, before it starts?

Exciting new research in the Journal of the International Society for Sports Medicine found that curcumin, one of the active ingredients in the spice turmeric, could significantly decrease muscle injury due to over-activity.

Twenty healthy, active men were given either a placebo or one gram of curcumin twice daily. They were given the supplement or placebo starting 48 hours prior to a 45-minute downhill running race and for 24 hours after the athletic test to determine whether curcumin could prevent delayed-onset muscle soreness (DOMS).

The study scientists chose the activity of downhill running because it is known to for its ability to forcibly lengthen muscles while they are in the midst of contracting, causing a stress on the body that triggers inflammation and the production of damaging free radicals which causes muscle pain and inflammation.

Muscle damage following the period of activity was assessed using magnetic resonance imaging (MRI). Muscle damage was also assessed using blood tests and microscopic cell and tissue analyses 48 hours after the athletic tests. Participants also reported their levels of pain before and after the running test. The scientists found that significantly fewer people in the curcumin group showed MRI evidence of muscle injury. They also found that the curcumin group had fewer markers of muscle damage or inflammation from over-exercising. This study suggests that curcumin can help prevent and heal muscle injuries, potentially even before they settle in. The study size was small but the results were impressive and warrants further research.

In a previous study in the Journal of Pain Research, curcumin has demonstrated a potent pain-relieving effect, even greater than 500 mg of acetaminophen. This new study shows that not only is curcumin an effective pain-relieving natural remedy, it also helps prevent and heal muscle injuries and inflammation.

The study dose was one gram of curcumin twice daily.

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